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CoQ10 and glutathione directly neutralize ROS at complex III, reducing superoxide leakage and thereby mitigating oxidative stress, which prevents pathological angiogenesis associated with it 50,51

Direct binding of copper ions to fatty acylated components in the tricarboxylic acid (TCA) cycle results in protein aggregation and dysregulation (40), blocking the TCA cycle and inducing proteotoxic stress and cell death (Fig